"It's more of the same, but we're a lot older," Miller joked with ET's Leanne Aguilera at the event in Pasadena, California. "That's the twist."
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Fox is bringing back the popular series for a new nine-episode season with Miller and Purcell reprising their roles as Michael Scofield and Lincoln Burrows for the latest chapter in the brothers' saga.
"We are like brothers at this point," Miller said. "When I see him, there's a level of comfort and familiarity that is like when I get together with family. I know that he has my back and I have his, and we get each other's rhythm and style. We have a shorthand on set, so there's a layer of comfort when I work with Dom."
While Miller is confident that newcomers will enjoy the show, he noted that there are Easter eggs that will enable fans of the original series to enjoy it on a deeper level.Read more at Entertainment Tonight