Macron's centrist Republic on the Move (LREM) party and its center-right Modem ally won 350 out of 577 seats in the lower house, after a record low turnout for a parliamentary ballot in the postwar Fifth Republic.
Government spokesman Christophe Castaner said the high abstention rate -- more than 50 percent of voters stayed at home -- was a failure for the political class and highlighted the need to change politics in France.
"The real victory wasn't last night, it will be in five years' time when we have really changed things," Castaner told RTL radio.
Though lower than forecast by pollsters, Macron's majority swept aside France's main traditional parties, humiliating the Socialist and conservative The Republicans party that had alternated in power for decades.
"Victory for the Center" read the headline of the left-leaning Liberation newspaper. Financial paper Les Echos' banner read "The Successful Gamble".
Castaner said Prime Minister Edouard Philippe and his government would resign later in the day and a new cabinet be formed in coming days.Read more at Reuters